The Metabolic Syndrome in an Elite African Community

Metabolic syndrome is a combination of metabolic disorders which increase the risk of developing cardiovascular disease and type 2 diabetes; two common causes of morbidity and mortality all over the world; with increasing incidence in sub-Saharan Africa. This study was carried out to determine the prevalence of metabolic syndrome in an elite Nigerian community and determine independent predictors of the condition. A cross-sectional study was designed involving 200 members of the community. They responded to a structured questionnaire on their demographic parameters as well as medical and drug histories. Fasting blood glucose; triglycerides; LDL-cholesterol; HDL-cholesterol and Total cholesterol were measured. Blood pressure; BMI and waist circumference were also measured. Using the IDF definition i.e presence of central adiposity and two of raised TG (?1.7 mm/L); reduced HDL (1.03 mm/L in men and 1.29 mm/L in women); raised blood pressure (130 mmHg systolic or 85 mmHg diastolic; or an antihypertensive drugs); and raised fasting blood glucose (5.6mm/L or previously diagnosed type 2 diabetes); a total of 35 persons were found to have metabolic syndrome. The commonest lipid abnormality found was reduced HDL levels. Raised BMI was a strong predictor (18). The study shows that while the prevalence of metabolic syndrome is low in the community; a large number of people have central obesity and high BMI. It is important for stakeholders to create awareness on the need to keep fit. There is also a need to carry out more studies on independent determinants of metabolic syndrome and seek to understand the pathways by which it develops; so as to be able to address it's far reaching implications

Invasive Bacteria Isolates from Children with Severe Infections in a Nigerian Hospital

Background: Little information is available about the aetiology and epidemiology of serious bacterial infections in Nigeria. This study determined bacterial isolates from blood and cerebrospinal fluid (CSF) of children presenting in the emergency room of a teaching hospital in Nigeria. Method: From October 2005 to December 2006; children aged two to 60 months presenting with signs of acute systemic infections were recruited. Blood culture and CSF specimens were collected and processed using standard microbiological protocols. Data were analysed using SPSS version 11 software. Results: Two hundred and two blood and 69 CSF samples were cultured. Fifty-five (27) of the blood cultures yielded Gram-negative bacilli and Gram-positive cocci in almost equal proportions. The most common isolates from the blood cultures were Staphylococcus aureus; 26 (12.9) and atypical coliforms; 13 (6.5). Others are Klebsiella spp; 3 (1.5); Klebsiella pneumonia; 2 (1.0); Escherichia coli; 3 (1.5); Enterobacter agglomerans; 2 (1.1); Proteus mirabilis; 2(1); Pseudomonas spp; 2 (1.0); Haemophilus influenza; 1 (1.0); and Coagulase-negative Staphylococcus; 1 (1.0). Fourteen out of 67 (20.9) of the CSF samples yielded bacterial isolates: Streptococcus pneumonia; 3 (4.5); Haemophilus influenza; 8 (11.9); Hemophilus spp; 1 (1.5); E. Coli; 1 (1.5); and atypical coliform; 1 (1.5). Gram-negative coliform isolates were predominantly resistant to penicillin based antibiotics and co-trimoxazole but sensitive to third-generation cephalosporins and quinolones. A high percentage of S. aureus isolates were multi-drug resistant. Conclusions: Bacterial infections contribute to the significant morbidity among children in our environment. S. aureus was more frequently isolated in sepsis while H. influenzae appears to play a major role in meningitis. Appropriate use of antibiotics is needed to manage affected children effectively. We also recommend improved vaccine coverage of children under the age of five years) of the blood cultures yielded Gram-negative bacilli and Gram-positive cocci in almost equal proportions. The most common isolates from the blood cultures were Staphylococcus aureus; 26 (12.9) and atypical coliforms; 13 (6.5). Others are Klebsiella spp; 3 (1.5); Klebsiella pneumonia; 2 (1.0); Escherichia coli; 3 (1.5); Enterobacter agglomerans; 2 (1.1); Proteus mirabilis; 2(1); Pseudomonas spp; 2 (1.0); Haemophilus influenza; 1 (1.0); and Coagulase-negative Staphylococcus; 1 (1.0). Fourteen out of 67 (20.9) of the CSF samples yielded bacterial isolates: Streptococcus pneumonia; 3 (4.5); Haemophilus influenza; 8 (11.9); Hemophilus spp; 1 (1.5); E. Coli; 1 (1.5); and atypical coliform; 1 (1.5). Gram-negative coliform isolates were predominantly resistant to penicillin based antibiotics and co-trimoxazole but sensitive to third-generation cephalosporins and quinolones. A high percentage of S. aureus isolates were multi-drug resistant.Conclusions: Bacterial infections contribute to the significant morbidity among children in our environment. S. aureus was more frequently isolated in sepsis while H. influenzae appears to play a major role in meningitis. Appropriate use of antibiotics is needed to manage affected children effectively. We also recommend improved vaccine coverage of children under the age of five years

Utilization of Primary Health Care Facilities: Lessons from a Rural Community in Southwest Nigeria

Background: This study assessed service/organisational factors and clients' perceptions that influenced utilisation of Primary Health Care (PHC) facilities in a rural community in Nigeria. Method: A cross-sectional household survey in the community as well as key-informant interviews of opinion leaders and health care providers and participant observations of health facilities and utilisation pattern was used to collect data. Results: Forty-four percent of respondents to the survey who were ill in the preceding six months visited a PHC facility for treatment; while others relied on self-medication/self-treatment. Education was positively associated with utilisation of PHC services (P0.05). Maternal and child health (45.4); prompt attention (23.0); and appropriate outpatient (20.5) services attracted respondents to use PHC services. Poor education about when to seek care; poverty; perceived high cost of PHC services; lack of drugs and basic laboratory services; and a regular physician on site at the facility were identified as barriers to utilisation. Conclusion: We conclude that community perceptions of poor quality and inadequacy of available services was responsible for low use of PHC services